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Liya Agustin Umar

X chromosome is a sex chromosome found in both women and me n. The inactivation
of the X chromosome is linked to a non-coding region of RNA known as the XIST
gene (X-inactive specific transcript). This gene is located in the X inactivation center
(XIC X-inactive center). The XIST gene is a region that belongs to the RNA group,
non-coding transcripts (NCT), also known as microRNA. Breast cancer (Breast
Cancer) is a type of cancer that commonly affects women, but men can develop
breast cancer, but the chances are small, about 1 in 1000. Breast cancer is a
cancerous neoplasm that is malignant, and occurs in the mammary gland. The
presence of a specific XIST gene on the X chromosome and the prevalence of breast
cancer, which is mostly in women, raises the idea that there is an influence of this
gene on breast cancer (breast cancer) in the epigenetic process. The XIST gene
related to microRNA has an opportunity to be looked at because certain microRNAs
have a greater or lesser level (concentration) in cancer cells than normal cells. This
is a new opportunity to continue to be developed as a consideration for a new
treatment method involving gene therapy.

Keywords: X Chromosome Inactivation XIST Breast cancer MicroRNA Epigenetic