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Rachmat Hidayat
Lusia Hayati

The cell cycle is a vital process in the life of every organism. Normally, the cell cycle
results in cell division. Cell division consists of 2 main processes, namely DNA
replication and chromosome division that has been duplicated into 2 daughter cells.
Cyclin is expressed periodically so that the cyclin concentration varies at each phase of
the cell cycle. Cdks are threonine or serine protein kinases which must bind to cyclin
for its activation. The concentration of Cdks is relatively constant during the cell cycle.
Cyclin-dependent kinase inhibitor (CKI) is a protein that can inhibit Cdk activity by
binding to Cdk or the cyclin-Cdk complex

Keywords: Cell cycle Cdk CKI Rb and p53 pathuxy