Hyperlipidemia is a condition when high level of blood lipids and causes morphological
changes in spermatozoa. Red dragon fruit (Hylocereus Polyrhizus) is one of the plants
as a source of antioxidants and has unsaturated fat content that is needed in the
spermatozoa maturation process. The aims of this the study is to determine the benefits
of red dragon fruit extract on the motility of white rat spermatozoa (Rattus norvegius)
induced by high-fat diet. The study is design by true experimental research and
research only testing group design. This research conducted in the Pharmacology and
Therapy Laboratory, Padjajaran University Education Hospital, in January 2020 using
white rats, male . ± 8 weeks wistar strains weighing ± 200-250. The study sample was
divided into several groups such group I as a control, group II as a negative control,
group III as positive group with simvastatin dose 0.72 mg / day, group IV as research
group 1 using red dragon fruit extract dose of 60 mg / 200 grBB / day for 52 days, and
group V as group 2 therapy using dragon fruit extract dose of 60 mg / 200grBB / day
for 104 days. The results showed that the mean percentage of motility of rat
spermatozoa increased in the relief group with the supplement of red dragon fruit
extract by dosing of 60 mg / 200 grBB / day for 104 days, or 51, 2%. This study
conclude that red dragon fruit has a superior effectivity better than simvastatin in
increasing the motility of spermatozoa.