Cellular Mechanisms of Spatial Memory Recovery via Hyperbaric Oxygen Therapy in Experimental TBI: A Review
Main Article Content
Traumatic Brain Injury (TBI) impairs spatial memory, affects individuals' quality of life, and increases disability and mortality rates. Hyperbaric Oxygen Therapy (HBOT), which delivers nearly 100% oxygen in a pressurised environment, has a potential intervention to ameliorate these cognitive deficits. This narrative review presents evidence from animal studies demonstrating the efficacy of HBOT in enhancing spatial memory in rats with TBI. Specifically, we present evidence that HBOT increases levels of Brain-Derived Neurotrophic Factor (BDNF) and activates the Hypoxia-Inducible Factor 1-alpha (HIF-1α) pathway. These molecular changes foster neuroplasticity and reduce oxidative stress, thereby promoting the repair and growth of dendritic spines and decreasing Reactive Oxygen Species (ROS) levels to prevent neuronal death. By elucidating these mechanisms, this review shows how HBOT contributes to spatial memory recovery in TBI, suggesting a promising therapeutic avenue that need further clinical exploration to refine treatment protocols and evaluate its applicability in human TBI recovery.
Keywords:
Brain injury
Hyperbaric oxygen therapy
Memory recovery
Neuroplasticity
Oxidative stress
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30. Ortega MA, Fraile-Martinez O, García-Montero C, Callejón-Peláez E, Sáez MA, Álvarez-Mon MA, et al. A general overview on the hyperbaric oxygen therapy: applications, mechanisms and translational opportunities. Medicina (Lithuania). 2021;57(9).
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32. Liu S, Liu Y, Deng S, Guo A, Wang X, Shen G. Beneficial effects of hyperbaric oxygen on edema in rat hippocampus following traumatic brain injury. Exp Brain Res. 2015;233(12):3359–65.
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35. Zhang X, Wang X, Sun X, Sun X, Zhang Y, Zhang H. Differences in cognitive function of rats with traumatic brain injuries following hyperbaric oxygen therapy. Medical Science Monitor. 2016;22:2608–15.
36. Fu Q, Duan R, Sun Y, Li Q. Hyperbaric oxygen therapy for healthy aging: from mechanisms to therapeutics. Redox Biol. 2022;53:102352.
37. Wang RY, Yang YR, Chang HC. The SDF1-CXCR4 axis is involved in the hyperbaric oxygen therapy-mediated neuronal cells migration in transient brain ischemic rats. Int J Mol Sci. 2022;23(3):1780.
38. Chiang MK, Lin TC, Lin KH, Chang YC, Hsieh-Li HM, Lai DM. Hyperbaric oxygen therapy attenuated the motor coordination and cognitive Impairment of polyglutamine spinocerebellar ataxia SCA17 Mice. The Cerebellum. 2023;23(2):401–17.
39. Giesler LP, Mychasiuk R, Shultz SR, McDonald SJ. BDNF: new views of an old player in traumatic brain injury. The Neuroscientist. 2023;107385842311649.
40. Zagrebelsky M, Tacke C, Korte M. BDNF signaling during the lifetime of dendritic spines. Cell Tissue Res. 2020;382(1):185–99.
41. Glasgow SD, Ruthazer ES, Kennedy TE. Guiding synaptic plasticity: novel roles for netrin‐1 in synaptic plasticity and memory formation in the adult brain. J Physiol. 2021;599(2):493–505.
2. Centers for Disease Control and Prevention. Moderate and Severe TBI. 2022 [cited 2024 May 7]. Available from: https://www.cdc.gov/traumaticbraininjury/moderate-severe/index.html
3. Iggena D, Jeung S, Maier PM, Ploner CJ, Gramann K, Finke C. Multisensory input modulates memory-guided spatial navigation in humans. Commun Biol. 2023 Nov 14;6(1):1167.
4. Min JH, Shin YI. Treatment and rehabilitation for traumatic brain injury: current update. Brain & Neurorehabil. 2022;15(2):e14.
5. Harch PG. New scientific definitions: hyperbaric therapy and hyperbaric oxygen therapy. Medical Gas Research. 2023 Apr 1;13(2):92-3.
6. Jeremic R, Pekovic S, Lavrnja I, Bjelobaba I, Djelic M, Dacic S, et al. Hyperbaric oxygenation prevents loss of immature neurons in the adult hippocampal dentate gyrus following brain injury. Int J Mol Sci. 2023;24(5).
7. Sakas R, Dan K, Edelman D, Abu-Ata S, Ben-Menashe A, Awad-Igbaria Y, et al. Hyperbaric oxygen therapy alleviates memory and motor impairments following traumatic brain Injury via the modulation of mitochondrial-dysfunction-induced neuronal apoptosis in rats. Antioxidants. 2023;12(12):2034.
8. Capizzi A, Woo J, Verduzco-Gutierrez M. Traumatic brain injury: an overview of epidemiology, pathophysiology, and medical management. Med Clin North Am. 2020 Mar;104(2):213–38.
9. Minister of Health of the Republic of Indonesia. National Guidelines management of traumatic brain injury. 2022 [cited 2024 May 7]. Available from: https://www.kemkes.go.id/id/pnpk-2022---tata-laksana-cidera-otak-traumatik
10. Jarrahi A, Braun M, Ahluwalia M, Gupta R V., Wilson M, Munie S, et al. Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions. Biomedicines. 2020;8(10):389.
11. Macedo FL, Figueredo LF, Villegas-Gomez GA, Arthur M, Pedraza-Ciro MC, Martins H, et al. Pathophysiology-based management of secondary injuries and insults in TBI. Biomedicines. 2024 Feb 26;12(3):520.
12. Montana JI, Tuena C, Serino S, Cipresso P, Riva G. Neurorehabilitation of spatial memory using virtual environments: A systematic review. J Clin Med. 2019 Oct 1;8(10):1516.
13. Nonaka M, Taylor WW, Bukalo O, Tucker LB, Fu AH, Kim Y, et al. Behavioral and myelin-related abnormalities after blast-induced mild traumatic brain injury in mice. J Neurotrauma. 2021;38(11):1551–71.
14. Rigon A, Schwarb H, Klooster N, Cohen NJ, Duff MC. Spatial relational memory in individuals with traumatic brain injury. J Clin Exp Neuropsychol. 2020 Jan 2;42(1):14–27.
15. Kumar J, Patel T, Sugandh F, Dev J, Kumar U, Adeeb M, et al. Innovative Approaches and Therapies to Enhance Neuroplasticity and Promote Recovery in Patients with Neurological Disorders: A Narrative Review. Cureus. 2023;15(7):e41914.
16. Qiao C, Liu Z, Qie S. The implications of microglial regulation in neuroplasticity-dependent stroke recovery. Biomolecules. 2023;13(3):571.
17. Schottlender N, Gottfried I, Ashery U. Hyperbaric oxygen treatment: effects on mitochondrial function and oxidative stress. Biomolecules. 2021;11(12):1827.
18. Fan G, Liu M, Liu J, Huang Y. The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: glutamate accumulation. Frontiers in molecular neuroscience. 2023;16:1113081.
19. Ge Y, Chen W, Axerio-Cilies P, Wang YT. NMDARs in cell survival and death: implications in stroke pathogenesis and treatment. Trends Mol Med. 2020;26(6):533–51.
20. Carlsson R, Enström A, Paul G. Molecular regulation of the response of brain pericytes to hypoxia. Int J Mol Sci. 2023 Mar 1;24(6).
21. Morishima M, Fujita T, Osagawa S, Kubota H, Ono K. Enhanced BDNF actions following acute hypoxia facilitate HIF-1α-dependent upregulation of Cav3-T-yype Ca2+ channels in Rat cardiomyocytes. Membranes (Basel). 2021 Jun 25;11(7):470.
22. Lin PH, Kuo LT, Luh HT. The roles of neurotrophins in traumatic brain injury. Life. 2021;12(1):26.
23. Akcay G. Weight Drop Models in Traumatic Brain Injury. Middle Black Sea Journal of Health Science. 2023;9(2):375–84.
24. Najem D, Rennie K, Ribecco-Lutkiewicz M, Ly D, Haukenfrers J, Liu Q, et al. Traumatic brain injury: Classification, models, and markers. Biochemistry and Cell Biology. 2018;96(4):391–406.
25. Ellenbroek B, Youn J. Rodent models in neuroscience research: is it a rat race? Dis Model Mech. 2016 Oct 1;9(10):1079–87.
26. Janvier Lab. Long Evans. 2024. Available from: https://janvier-labs.com/en/fiche_produit/long-evans_rat/
27. Kirby JP, Snyder J, Schuerer DJ, Peters JS, Bochicchio GV. Essentials of hyperbaric oxygen therapy: 2019 review. Missouri medicine. 2019;116(3):176.
28. Levitan DM, Hitt M, Geiser DR, Lyman R. Rationale for hyperbaric oxygen therapy in traumatic injury and wound care in small animal veterinary practice. Journal of Small Animal Practice. 2021;62(9):719-29.
29. Hadanny A, Efrati S. The Hyperoxic-hypoxic paradox. Biomolecules. 2020;10(6):958.
30. Ortega MA, Fraile-Martinez O, García-Montero C, Callejón-Peláez E, Sáez MA, Álvarez-Mon MA, et al. A general overview on the hyperbaric oxygen therapy: applications, mechanisms and translational opportunities. Medicina (Lithuania). 2021;57(9).
31. Cannellotto M, Yasells García A, Landa MS. Hyperoxia: effective mechanism of hyperbaric treatment at mild-pressure. Int J Mol Sci. 2024;25(2):777.
32. Liu S, Liu Y, Deng S, Guo A, Wang X, Shen G. Beneficial effects of hyperbaric oxygen on edema in rat hippocampus following traumatic brain injury. Exp Brain Res. 2015;233(12):3359–65.
33. Liu S, Shen GY, Deng SK, Wang X Bin, Wu QF, Guo AS. Hyperbaric oxygen therapy improves cognitive functioning after brain injury. Neural Regen Res. 2013;8(35):3334–43.
34. Harch PG, Kriedt C, Van Meter KW, Sutherland RJ. Hyperbaric oxygen therapy improves spatial learning and memory in a rat model of chronic traumatic brain injury. Brain Res. 2007;1174(1):120–9.
35. Zhang X, Wang X, Sun X, Sun X, Zhang Y, Zhang H. Differences in cognitive function of rats with traumatic brain injuries following hyperbaric oxygen therapy. Medical Science Monitor. 2016;22:2608–15.
36. Fu Q, Duan R, Sun Y, Li Q. Hyperbaric oxygen therapy for healthy aging: from mechanisms to therapeutics. Redox Biol. 2022;53:102352.
37. Wang RY, Yang YR, Chang HC. The SDF1-CXCR4 axis is involved in the hyperbaric oxygen therapy-mediated neuronal cells migration in transient brain ischemic rats. Int J Mol Sci. 2022;23(3):1780.
38. Chiang MK, Lin TC, Lin KH, Chang YC, Hsieh-Li HM, Lai DM. Hyperbaric oxygen therapy attenuated the motor coordination and cognitive Impairment of polyglutamine spinocerebellar ataxia SCA17 Mice. The Cerebellum. 2023;23(2):401–17.
39. Giesler LP, Mychasiuk R, Shultz SR, McDonald SJ. BDNF: new views of an old player in traumatic brain injury. The Neuroscientist. 2023;107385842311649.
40. Zagrebelsky M, Tacke C, Korte M. BDNF signaling during the lifetime of dendritic spines. Cell Tissue Res. 2020;382(1):185–99.
41. Glasgow SD, Ruthazer ES, Kennedy TE. Guiding synaptic plasticity: novel roles for netrin‐1 in synaptic plasticity and memory formation in the adult brain. J Physiol. 2021;599(2):493–505.
