Nanoparticles size can make easier for drugs to enter and react quickly to the body.
In this study, nanoparticles Carica papaya L. leaf were used and combined with
chitosan 1%. The aim of this study was to measure the effectiveness of the
combination of nanoparticles from Carica papaya L. leaf and chitosan 1% against
fibroblasts in the tooth socket of Wistar rats. Carica papaya L. leaf extract was
made by maceration method and converted into a concentration of 25%, 50%, 75%
and 100%, then made into nanoparticles using the nanoemulsion method. Chitosan
1% was made using Na-TPP solvent using the ionic gelation method with a ratio of
2:1 and after that it was mixed with nanoparticles of Carica papaya L. leaf then
made into a gel preparation. The ANOVA statistical test shows a significant number
of p <0.05, so it can be ignored that the increase in the number of fibroblast cells
produced by the nano gel extract is 25%, 50%, 75% and 100%, its 138, 173, 177.4
and 328. Thus, the combination of 100% Carica papaya L. leaf nanoparticle extract
and 1% nanocitosan was the most effective in increasing fibroblast cells on Wistar
rat tooth socket.